But too much cholesterol can pose a problem. Where is cholesterol synthesized? Cholesterol comes from two sources. Cholesterol is essential for all living organisms. Previous question Next question Get more help from Chegg. The remainder of the cholesterol in your body comes from foods from animals. Cholesterol can both be synthesized endogenously and obtained from the diet. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as Mycoplasma, which require cholesterol for growth. Expert Answer . Acetyl-CoA is produced from glucose by the same sequence of reactions used to produce cytosolic acetyl-CoA for fatty acid biosynthesis. Cholesterol is synthesized by virtually all tissues in human, although liver, intestine, adrenal cortex, reproductive organs (testis and ovaries) and placenta make largest contributions to the body’s cholesterol pool. Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the total daily cholesterol requirement (~1 gram). In vertebrates, hepatic cells typically produce the greatest amounts. Click here to read more. Cholesterol can also be obtained from food. Cholesterol is synthesized from cytosolic acetyl-CoA by a sequence of reactions: Glucose is a major source of carbon for acetyl-CoA. The molecule. Cholesterol is a tetracyclic alcohol and a type of sterol.Added to the sterol frame with the alcohol group at position 3 are 2 methyl groups at carbon positions 10 and 13 and a 2-isooctyl group at position 17. These are cholic acid (found in the largest amount) and chenodeoxycholic acid (Figure 26–7). The total number of stereocenters is 8. A typical North American diet contains approximately 450mg of cholesterol per day (of which 55% is absorbed), while cholesterol synthesis on such a modest cholesterol diet is 11–13mg/kg/day. Most of the cholesterol used by active adults is produced in the liver, which produces ~70% of daily cholesterol demand (~1 gram). Biosynthesis of cholesterol commonly happens in the endoplasmic reticulum of hepatic cells. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D.Cholesterol is the principal sterol synthesized by all animals. It’s not inherently “bad.” Your body needs it to build cells and make vitamins and other hormones. Note that significant amounts of cholesterol only occur in meat, eggs, and milk products; plants and mushrooms contain other sterols but very little cholesterol. Cholesterol is present in tissues and in plasma either as free cholesterol or combined with a long-chain fatty acid as cholesteryl ester, the storage form. Your liver makes all the cholesterol you need. The molecule is unsaturated at position 5,6 with an alkene group. Cholesterol is a waxy substance. 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